Salvia lyrata (lyre-leaf sage, lyreleaf sage, wild sage, cancerweed), is a herbaceous perennial in the family Lamiaceae that is native to the United States, from Connecticut west to Missouri, and in the south from Florida west to Texas. It was described and named by Carl Linnaeus in 1753.

Salvia lyrata forms a basal rosette of leaves that are up to 8 inches (20 cm) long, broadening toward the tip. The leaves have irregular margins and are typically pinnately lobed or cut, looking somewhat like a lyre. The center vein is sometimes dark wine-purple. A square-shaped hairy stem up to 2 feet (0.61 m) long grows from the rosette, with uneven whorls of two-lipped lavender to blue flowers. Flowering is heaviest between April and June, though sparse flowering can happen throughout the year.